Effect of Systemic Zoledronic Acid Dosing Regimens on Bone Regeneration in Osteoporotic Rats

The aim of this study was to evaluate the regeneration bone defects created in femoral condyle osteoporotic rats, following intravenous (IV) zoledronate (ZA) treatment three settings: pre-bone grafting (ZA-Pre), post-bone (ZA-Post), and pre- plus (ZA-Pre+Post). Twenty-four female Wistar rats were ovariectomized (OVX). After 12 weeks, left condyle. All grafted with a particulate inorganic cancellous bovine substitute. ZA (0.04 mg/kg, weekly) administered six 4 weeks graft placement. To another given placement creation continued for 6 weeks. Additional received Control animals weekly saline injections. At placement, samples retrieved histological evaluation area percentage (BA%) remaining (RBG%). BA% ZA-Pre (50.1 ± 3.5%) ZA-Post (49.2 8.2%) significantly increased compared that controls (35.4 5.4%, p-value 0.031 0.043, respectively). In contrast, ZA-Pre+Post (40.7 16.0%) showed similar (p = 0.663). For RBG%, all experimental groups results ranging from 36.3 47.1%. Our data indicate or post-surgical systemic IV administration improves bovine-bone particles conditions. However, no favorable effect on repair seen treatment.